AVF Chemical Industrial CO.,LTD

Vitamin K3 (MSB)

Chemical name: Menadione Sodium Bisulfite( MSB)
Molecular formula : C11H8O2種aHSO33H20
Executive standard: PRC National Standard GB7294-87
Item and Index

Aspects:
white crystal power, no smell, water-soluble, not dissolved in ethanol, hardly dissolved in aether
and benzene, stable in normal temperature, easily decomposed under light, stimulating skin and respiratory tract.

Efficacy:It facilitate the formation of thrombin so as to speedup or maintain the normal concretion time of blood. As well as lowering blood pressure,it is also diuretic and strengthen liver抯 detoxification ability. Deficiency of VK3 will lead to longer concretion time of blood or to bleeding nonstop. That means even very small wounds may lead to the breach of blood vessels, resulting in extensive observable under-skin bleeding and bleeding of other apparatuses or organs such as:muscles, brain, stomach, intestines, abdomen, urinary system, genital system and so on. More seriously, it may lead to hematuria and anaemia, even death.

Reservation: Reserved in a place that is shabby and cool, lightproof and dry.
Guarantee period:
One year. Please use it as soon as possible after unpacking for fear of metamorphose.
Packaging: 25kgs carton

Vitamin K 3 (MNB)
Base on MSB, combining niacinamide molecular groups, MNB replaces sodium ion and 3 crystal water in MSB. For one thing, this eliminates the presence of water molecule which is the main factor of product instability. For another thing, big molecular group blocks the way isomer transforms, which restrains isomer from coming into being. Also, the presence of supportive molecule group favors the transformation and absorb of VK3 in organisms.
Chemical name: Menadione Nicotinamide Bisulfite(MNB)
Molecular formula: C17H16O6N2S
Molecular weight: 376.23
Physical characteristics: White crystal power, little water soluble(1.3g/100ml), easily dissolved in ethane and chloroform.

MNB unique advantage: Based on MSB, combined with niacinamide molecular group, MNB has higher stability and bioactivity. It also saves the separate quantity of the addition of niacinamide.

Reservation:Airproof avoiding light, heat and moisture. Under original packing, the guarantee period is 12 months. However it should be used as soon as possible after unpacked.

Type:

Type	menadione content	Nicotinamide content	specs	Guarantee period	packing	recommendation
MNB96	43.9%	30.0%	25kg	12 months	Cardboard barrel	3-8.0mg/kg
MNB50	22.9%	16.0%				3-12mg/kg

High bioactivity:

The concretion time of blood is in the inverse ratio with the bioactivity of VK3.The concretion time of blood of different type of VK3 with different concentration (PPT/sec.)

VK3 concentration(mg/kg)	MNB	MSB
0.10	52	78
0.20	34	56
0.40	29	35

More excellent stability:

1, the stable time of MNB and MSB in feedstuff mixed with vitamin:
Add MSB and MNB with the same menadione content to feedstuff mixed with vitamin, and airproof the swatches in room temperature for 4 months, the result is as follows: (ratio of reservation)

VK3 sourse	1month later	2months later	3months later	4months later
MNB	97.5%	90%	85%	83%
MSB	79%	61%	46%	32.5%

2, the effect of graininess and reservation of feedstuff to the stability of MSB and MNB:
Taking pig feedstuff for example: (content of MSB or MNB)

Type of additive	Before grained	Number of days after grained
		0	15	30
MNB	100%	94%	83%	78%
MSB	100%	61%	33%	29%